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Anticancer Drugs
Organic
A2
Amino Acids, Proteins & DNA
AQA Content
Explain why cisplatin prevents DNA replication
Explain why such drugs can have adverse effects.
Specification Notes
The Pt(II) complex cisplatin is used as an anticancer drug.
Cisplatin prevents DNA replication in cancer cells by a ligand replacement reaction with DNA in which a bond is formed between platinum and a nitrogen atom on guanine.
Society needs to assess the balance between the benefits and the adverse effects of drugs, such as the anticancer drug cisplatin.
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